Amfebutamone(also known as bupropion)is structurally related to an amphetamine psychostimulant. Many people think that amfebutamone is relative to Methamphetamine. But they are completely different substances. Amfebutamone is a new kind of antidepressant. It also can be used to quit smoking. But Methamphetamine is a kind of stimulant. Purchase and sale are prohibited.
Now we will introduce some information about amfebutamone. There are so many names about it. For example:1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone,2-tert-butylamino-1-(3-chlorophenyl)-propan-1-one,Wellbutrin,(a-2-(tert-butylamino)-3¢-chloropropiophenone,m-chloro-a-(tert-butylamino)propiophenone,2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one.
Other information is below:
Molecular weight: 239.74
Product Characteristics: Pale yellow oily substance. Easy to absorb moisture, easy to decompose. Soluble in methanol, ethanol, acetone, ether or benzene.
Manufacture method: In ethyl magnesium bromide solution, adding the diethyl ether solution of o-chlorophenonitrile reaction,the reaction solution is hydrolyzed with cold dilute hydrochloric acid, steam to remove the ether, the remaining aqueous solution is reheated for a certain time. Cool and add seed. The solids were collected by filtration, washed with cold water, and recrystallized with methanol to obtain o-chlorophenone. Dissolve o-chlorophenone in dichloromethane, stir with activated carbon and magnesium sulfate, and filter. Add brominated methylene chloride solution under agitation. When the bromine color disappears completely, the solvent is removed by vacuum concentration, and the remaining oily substance is o-chloro-Cr bromophenylaceetone. O-choro-cr bromophenylacetone was dissolved in acetonitrile, and tert-butylamine acetonitrile solution was added. Set, add water and ether for distribution.After treatment, it is washed with acetone and recrystallized with a mixture of isopropyl alcohol and anhydrous ethanol. Wellbutrin hydrochloride.
Pharmacologic action: Bupropion had a weak inhibitory effect on norepinephrine, 5-HT and dopamine reuptake, but had no effect on monoamine oxidase. The mechanism of antidepressant action of this product is not clear, and may be related to norepinephrine and/or dopaminergic action.